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KMID : 1189420200330040001
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2020 Volume.33 No. 4 p.1 ~ p.15
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Aggravating and Mitigating Patient Factors Affecting Mild to ModerateAtopic Dermatitis
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Kang Dong-Won
Kim Yoon-Bum
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Abstract
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Objectives : To investigate aggravating and mitigating factors of atopic dermatitis and to utilize the outcome in treatment planning.
Methods : The research has a cross-sectional study design. Patients’ SCORing Atopic Dermatitis (SCORAD) Index, demographic, physical characteristics, social history, serologic index and skin related instrumental measurements were analyzed with correlation and regression analysis method.
Results : 48 patients in total were enrolled in the study. Skin Surface Hydration (SSH) and sex were found to be statistically significant aggravating and mitigating factors. As SSH increased, Total SCORAD (tSCORAD) and Objective SCORAD (oSCORAD) increased as well. As SSH decreased, tSCORAD and oSCORAD decreased as well. Female patient had a higher probability of suffering from severer subjective symptoms than that of male. Age, body mass index (BMI), alcohol consumption and smoking, transepidermal water loss (TEWL), IgE, IL-4, IL-5, IL-6, IFN-γ were found not to be statistically significant. There was no correlation between Subjective SCORAD (sSCORAD) and oSCORAD neither with Eczema Area and Severity Index (EASI).
Conclusions : Increasing cutaneous moisture should be included in the treatment plan of atopic dermatitis. More emphasis should be put on alleviating subjective discomforts of female patients than that of male. Establishing separate strategies of managing objective eczema status and subjective discomforts respectively should be considered.
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KEYWORD
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Atopic Dermatitis, SCORAD Index, Factor Analysis, Correlation, Aggravating Factor, Mitigating Factor, Skin Moisture
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